Effect of central obesity on serum lipid profile in non-diabetic, non-hypertensive subjects - A preliminary study

Authors

  • Kasuni Walatara Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka
  • Fathima Nusha Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka
  • Anusha Kaneshapillai Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka
  • Lohini Athiththan Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka
  • Rasika Perera Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka
  • Usha Hettiaratchi Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

DOI:

https://doi.org/10.31357/ijms.v1i1.2247

Abstract

Central obesity is a significant risk factor for metabolic syndrome in adults. Central fat distribution greatlyalters the lipid profile and induces atherogenic dyslipidaemia even in normoglycaemic, non-hypertensivesubjects. Hence, the aim of the present study was to identify the serum lipid parameters which are alteredwith central obesity in non-diabetic, non-hypertensive subjects in Sri Lanka. A cross-sectional study wasconducted at the Family Practice Centre of University of Sri Jayewardenepura, after obtaining ethicalclearance and informed written consent from 227 non-diabetics, non-hypertensive subjects who were not onStatins. Overnight fasting venous blood was collected and assayed for serum lipid profile such astriglycerides (TG), total cholesterol (TC) and high density cholesterol (HDL). Low density cholesterol (LDL)and TG/HDL ratio were calculated. Waist circumference (WC) was measured based on WHO and NHANESstandards. All data were analysed using SPSS (ver.17) software. Mean age of the subjects was 40.7 ± 13.7years and 59.9% were females. Obese males and females were 40.7% and 49.3% respectively. In the studysample, mean TG and TG/HDL ratio were significantly (p<0.05) higher in obese males. However, all meanserum lipid parameters such as TG, TC, LDL and TG/HDL ratio were higher in both obese males andfemales and HDL was lower in them. Hence, even in non-diabetic, non-hypertensive subjects, central obesityhas a relationship with altered lipid profile which could lead to obesity related metabolic abnormalities.

Keywords: central obesity, triglycerides, waist circumference.

Author Biographies

Kasuni Walatara, Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Fathima Nusha, Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Anusha Kaneshapillai, Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Lohini Athiththan, Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Rasika Perera, Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Usha Hettiaratchi, Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

Department of Biochemistry, University of Sri Jayewardenepura, Sri Lanka

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Published

2015-06-23