Investigation of the Structure of the Complex Oligomeric Mixture Formed During Grignard Tetramethylation of N-benzylphthalimide

Authors

  • Viraj C. Jayawardena ARC Center of Excellence for Free Radical Chemistry & Biotechnology, Faculty of Science & Engineering, Queensland University of Technology, 2 George Street, Brisbane, QLD 4001, Australia.

DOI:

https://doi.org/10.31357/ait.v3i2.7349

Abstract

TMIO or 1,1,3,3-tetramethylisoindolin-2-yloxyl (5, Scheme 1) is one of the most versatile isoindoline nitroxides due to its applications [1, 2] and a variety of important advantages such as thermal stability, low reactivity towards olefins [3], symmetrical nature [4], UV detectability [5] and relative inertness to free radical attack [4][4]. The most common and effective pathway for synthesizing 5 remains the Grignard-based approach in which N-benzylphthalimide 1 is treated with methylmagnesium halide in refluxing toluene, followed by subsequent debenzylation and oxidation of the resulting secondary amine

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Published

2024-04-08

How to Cite

Viraj C. Jayawardena. (2024). Investigation of the Structure of the Complex Oligomeric Mixture Formed During Grignard Tetramethylation of N-benzylphthalimide. Advances in Technology, 3(2). https://doi.org/10.31357/ait.v3i2.7349

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