Investigation of the Structure of the Complex Oligomeric Mixture Formed During Grignard Tetramethylation of N-benzylphthalimide
DOI:
https://doi.org/10.31357/ait.v3i2.7349Abstract
TMIO or 1,1,3,3-tetramethylisoindolin-2-yloxyl (5, Scheme 1) is one of the most versatile isoindoline nitroxides due to its applications [1, 2] and a variety of important advantages such as thermal stability, low reactivity towards olefins [3], symmetrical nature [4], UV detectability [5] and relative inertness to free radical attack [4][4]. The most common and effective pathway for synthesizing 5 remains the Grignard-based approach in which N-benzylphthalimide 1 is treated with methylmagnesium halide in refluxing toluene, followed by subsequent debenzylation and oxidation of the resulting secondary amine
Downloads
Published
How to Cite
License
Copyright (c) 2024 Viraj C. Jayawardena
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Authors hold the copyright of their manuscripts, and all articles are circulated under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, as long as that the original work is properly cited.
The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. The authors are responsible for securing any permissions needed for the reuse of copyrighted materials included in the manuscript.
