Preparation, Characterization, and in vitro Anti-arthritic Activity of Microcapsules Loaded with Bridelia retusa Aqueous Bark Extract for the Treatment of Rheumatoid Arthritis

Authors

  • Charuni R. Peiris Department of Pharmacy, Faculty of Allied Health Sciences, General Sir John Kotelawala Defence University, Kandawala Road, Dehiwala-Mount Lavinia 10390, Sri Lanka. Department of Cosmetic Sciences, Faculty of Health Sciences, CINEC Campus, Malabe, 10115, Sri Lanka.
  • Udara N. Wijayawickrema Department of Pharmacy, Faculty of Allied Health Sciences, General Sir John Kotelawala Defence University, Kandawala Road, Dehiwala-Mount Lavinia 10390, Sri Lanka.
  • Chathurika B.L. Samanmali Department of Pharmacy, Faculty of Allied Health Sciences, General Sir John Kotelawala Defence University, Kandawala Road, Dehiwala-Mount Lavinia 10390, Sri Lanka
  • Danushika C. Manatunga Department of Biosystems Technology, Faculty of Technology, University of Sri Jayewardenepura, Dampe–Pitipana Rd, Homagama, 10502, Sri Lanka. CAMD Research Laboratory, Department of Chemistry, Faculty of Science, University of Colombo, Colombo 00300, Sri Lanka.

DOI:

https://doi.org/10.31357/ait.v4i01.7861

Keywords:

aqueous bark extract, Bridelia retusa, microcapsules, rheumatoid arthritis, slow-release

Abstract

n this study, aqueous bark extract (ABE) of Bridelia retusa was encapsulated into the calcium alginate microcapsules.
Prepared microcapsules were characterized by scanning electron microscopic analysis and Fourier Transform-Infrared
(FT-IR) spectroscopy. The encapsulation efficiency, the release profile and the in vitro anti-arthritic activity of the
microcapsules were evaluated. Prepared microcapsules were in spherical appearance and the average size was found
to be less than 1 µm. The FT-IR analysis revealed the presence of ABE within the microcapsules while confirming the
cross-linking of the polymers. The maximum encapsulation efficiency of microcapsules was 8.34 ± 0.01% and the
cumulative release profile of microcapsules showed a prolonged releasing behavior. The anti-arthritic activity of ABEloaded microcapsules has shown a stronger anti-arthritic activity compared to the anti-arthritic activity of free ABE.
The slow release of ABE from microcapsules could promote a prolonged and increased anti-arthritic activity for the
treatment of Rheumatoid arthritis.

Downloads

Published

2025-01-08

How to Cite

Charuni R. Peiris, Udara N. Wijayawickrema, Chathurika B.L. Samanmali, & Danushika C. Manatunga. (2025). Preparation, Characterization, and in vitro Anti-arthritic Activity of Microcapsules Loaded with Bridelia retusa Aqueous Bark Extract for the Treatment of Rheumatoid Arthritis. Advances in Technology, 4(01). https://doi.org/10.31357/ait.v4i01.7861

Issue

Vol. 4 No. 01 (2024)

Section

Articles

Categories

License

Copyright (c) 2025 Charuni R. Peiris, Udara N. Wijayawickrema, Chathurika B.L. Samanmali, Danushika C. Manatunga

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Authors hold the copyright of their manuscripts, and all articles are circulated under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, as long as that the original work is properly cited.

The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. The authors are responsible for securing any permissions needed for the reuse of copyrighted materials included in the manuscript.


Most read articles by the same author(s)