The Atherogenic Index of Plasma (AIP), Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP) for assessment of Cardiovascular risk: A Comparative Analysis between Normal Subjects and Patients with Acute Myocardial Infarction

Abstract

Acute Myocardial Infarction (AMI) is caused by reduced blood flow in a coronary artery and it has been the leading cause for morbidity and mortality worldwide for the last 20 years.  Aim of this study was to compare the Atherogenic Index of Plasma (AIP), Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP) and lipid profile parameters between normal subjects and patients with AMI admitted to a tertiary care hospital in Sri Lanka and to find the correlations of AIP, VAI, LAP with lipid parameters.  A cross-sectional study was conducted involving a total of 100 patients with AMI and 100 age and gender matched healthy subjects of age between 18 and 85 years. Blood samples were drawn from patients with AMI admitted to Colombo South Teaching Hospital within 24 hours of the onset of chest pain. The total cholesterol (TC), triglycerides, LDL, and HDL were analyzed and used with BMI and waist circumference (WC) for calculating VAI, AIP and LAP. The HDL level of cases was significantly lower when compared to HDL level of control subjects (p<0.05). Significant differences were not observed in TC and LDL between cases and controls. The significant differences in Triglycerides, HDL, AIP, VAI and LAP were observed only between female patients with AMI and female control subjects (p<0.05). Mean AIP, VAI and LAP of cases showed significant correlations only with triglyceride and HDL.  The AIP, VAI, and LAP can be used for the assessment of cardiovascular risk in patients, especially in female subjects.

KEYWORDS: Atherogenic Index of Plasma (AIP), Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP), Acute myocardial infarction, Lipid profile