Correlation of Atherogenic Index of Plasma and Atherogenic Coefficient with Cardiovascular Disease Risk assessed by ASCVD Risk Calculator


  • Rahal Widanagamage Department of Medical Laboratory Science, Faculty of Allied Health Sciences, General Sir John Kotelawala Defence University
  • K.H.M. Silva
  • H.A.C. Ayeshmantha
  • K.U.G.D.M. Kariyawasam
  • R.A.N.K. Wijesinghe



Introduction: Cardiovascular disease (CVD) is the leading cause of approximately one-third deaths worldwide. Absolute lipid parameters are inadequate in predicting CVD risk and several lipid indices have been introduced namely “Atherogenic index of plasma” (AIP) and “Atherogenic coefficient” (AC). CVD risk of a patient for the upcoming 10 years can be calculated using atherosclerotic cardiovascular disease (ASCVD) risk calculator. Though, this method currently accepts as the gold standard, certain drawbacks have been reported. Therefore, the aim of this study was to investigate the correlation of AIP and AC with CVD risk estimation for the upcoming 10 years calculated by ASCVD risk calculator. Methods: Hundred and fifty-three patients were recruited for the study. Socio-demographic data were collected through interviewer-based questionnaire. Total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides values were obtained from the lipid profile test results of the study participants. AIP and AC were calculated using formulas while 10-year ASCVD risk was calculated by ASCVD risk calculator. Results: There was no significant correlation between AIP and 10-year ASCVD risk (p>0.05) and AC and 10-year ASCVD risk (p>0.05), but a significant correlation was observed between AIP and AC (Pearson’s correlation r=0.425, p<0.05). Conclusions: CVD risk of patients should be assessed routinely especially as it is overlooked in most patients presenting normal lipid profile variables, hence the actual risk remains silent unless it is properly investigated using laboratory investigations